The rate of wound healing in the large postoperative cavity after open-type operations on the middle ear with and without epidermal growth factor

Ognetov Sergey Yuryevich, Kravchuk Alexander Pavlovich, Davtyan Marat Barsegovich

The paper describes the problem of chronic purulent otitis media in ear surgery and methods of its elimination. The pros and cons of the solution methods are given. Examples from clinical literature are used. The use of epidermal growth factor makes it possible to achieve full-fledged epidermization of a large postoperative cavity obtained during open-type operations on the middle ear. The purpose of the study. To compare the rate of wound healing (epidermization) in a large postoperative temporal bone cavity (with a volume of more than 2 cubic cm) obtained after open-type operations on the middle ear using epidermal growth factor and without it. Materials and methods. The study involved 105 patients. All participants in the statistical observation underwent a general cavity sanitizing operation on the middle ear. After that, the patients were divided into 3 groups of 35 people. In the first third of the study patients, the drug "Ebermin" containing epidermal growth factor was used in local treatment (group 1), in others, local treatment was not used (group 2). In the third group of patients, silver sulfadiazine was prescribed for local treatment. The postoperative cavity was treated with medications on the 8th day after surgery. Otomicroscopy was used to evaluate the result of a clinical study (complete or incomplete epidermization of the postoperative cavity). The results of the study proved a significant positive effect of epidermal growth factor on the rate of wound healing (epidermization) in a large postoperative cavity obtained during open-type operations on the middle ear. The largest number of purulent-inflammatory complications in the postoperative period was observed in patients in the second group, which confirms the antimicrobial effect of silver sulfadiazine.

Keywords:epidermal growth factor, wound healing.