The effect of plant extracts on telomere length

Alkhaddur Aziz

The effect of the role of free radicals and inflammatory factors on the biological factors that contribute to telomere length changing, and consequently the effect of phytochemicals as reducing free radical levels and levels of inflammatory factors (especially cytokines) on telomere lengths was discussed. Human lymphocytes were cultured in the presence of extracts (grape seeds, pomegranate, garlic), Where the cultivation process was repeated three times (each time 72 h) . The effect of the role of oxidative stress and inflammatory factors on the biological factors that contribute to telomere length shortening, and consequently the effect of phytochemicals as reducing free radical levels and levels of inflammatory factors (especially cytokines) on telomere lengths was discussed. The results showed an increase in telomere lengths in lymphocytes by (3-5) times compared to the control after applying grape seed extract (1,2%,2,4%), while both pomegranate and garlic extracts had no effect. In the same context, pomegranate and grape seed extracts significantly reduce the intensity of chemiluminescence in human cells compared with the control. Therefore, it was linked between the concentrations of free radicals after applying grape seed extract and telomere lengths.

Keywords:Phytochemicals compounds, Telomere length, Free radicals, Chemiluminescence.