Melatonin and seasonal exacerbation of duodenal ulcer

Esedov Esed Mutagirovich, Musayeva Louise Nadirovna

Peptic ulcer of the duodenum is widespread, and is known for serious complications, sometimes incompatible with life. The aim of our study was to optimize the early diagnosis of duodenal ulcer (DU) with the determination of melatonin in the blood, depending on the seasonal exacerbation during the year. To study the prospects of using the hormone melatonin as an early diagnostic and prognostic marker of PUD. We have carried out a comprehensive examination with informed consent of 40 healthy volunteers (control group) and 60 patients with duodenal ulcer (main group). In the venous blood (with EDTA) of the examined persons, the concentration of the hormone melatonin was determined by high-performance liquid chromatography with tandem mass spectrometry (HPLC_MS) in different seasons of the year. In patients, the level of indole was below the threshold values, and the variation of the melatonin profile in different seasons of the year was different. So, in the spring-summer time, the content of melatonin in the blood was 10 pg/ml or less, while in the autumn-winter period it reached 1 pg/ml or less. Significant changes detected in patients allow us to recommend the determination of this indole as a biomarker for predicting seasonal exacerbation of duodenal ulcer.

Keywords:melatonin, duodenal ulcer, desynchronosis.