Molecular genetic studies of human bocaparvovirus in children with respiratory infection in the Republic of Belarus

Sivets Natallia

The study determined the nucleotide sequences of the complete genomes of HBoV1 circulating in our country. Sequence homology of Belarusian bocaparvoviruses with reverence strain ST2 (NC_007455.1) for BLR/Minsk/10/14, BLR/Minsk/11/14 and BLR/Mogilev/241/14 was 99.7%, for BLR/Gomel/ 285/15 was 99.8%. The presence of two unique substitutions P157S and D639K in the regions of the DNA-binding and helicase domains, which can affect the rate of replication and transcription of the respiratory bocaparvovirus.

Keywords:HBoV1, DNA, sequence reaction, genome, amino acid substitutions.