Comparative analysis of the causes of non-developing pregnancy – the view of obstetrician-gynecologist, pathomorphologist and cytogeneticist

Palyutina Elena Yurievna, Tikhomirova Svetlana Vladislavovna, Sotina Elena Mikhailovna, Kozlovskaya Irina Alexandrovna

we have performed a retrospective analysis of anamnestic data of 64 patients with non-developing pregnancy between 6 and 12 weeks of gestation with the results of extension pathomorphological and cytogenetic study. According to the results of a cytogenetic study, the chromosomal pathology has been detected in 45 (70.7%) samples. Prevailing types of disorders were trisomies 43.7% and triploidies 12.5%. According to the results of the extension pathomorphological study, the data on the chromosomal pathology have been detected in only 14 (20.3%) samples. The percentage of agreement is 33%. During the histologic study, the inflammatory process has been registered in 53% of cases. In this study pathological karyotype corresponded to a histologic pattern of inflammation in 38% of cases. In order to choose the right tactics of further treatment of patients with non-developing pregnancy, it is necessary to use at least 2 methods of study. Whenever possible they should be accompanied with molecular genetic and immunohistochemical diagnostic methods.

Keywords:non-developing pregnancy, cytogenetic study, morphological examination, karyotype.