Application catheterization of cavernous sinuses and PET for the diagnosis of ACTH-secreting pituitary adenomas

Tihonov K. V., Cherebillo V. Yu.

The article presents the results of the use of catheterization of cavernous sinuses and PET for the diagnosis of ACTH-secreting pituitary adenomas when MRI with contrast does not allow to visualize the tumor. Data analysis was carried out on patients hospitalized in the neurosurgical department of the I.P. Pavlov First St. Petersburg State Medical University from 2015 to 2022, who underwent endoscopic transsphenoidal adenomectomy for ACTH-secreting pituitary adenomas. Effective treatment of ACTH-secreting pituitary adenomas is necessary because this tumor is associated with the development of Itsenko-Cushing's disease, and in the absence of adequate and timely treatment and preservation of hypercorticism, 5-year mortality of these patients exceeds the general population, reaching 50%, therefore, an important aspect in treatment is timely and accurate diagnosis.

Keywords:Pituitary adenoma, ACTH secreting, corticotropinoma, selective blood sampling, catheterization of cavernous sinuses. Cushing's disease.