Clinical and laboratory features of autoimmune gastritis in Siberia

Belkovets Anna Vladimirovna, Kruchinina Margarita Vitalievna, Ozhiganova Natalya Vladimirovna, Shcherbakova Liliya Valerievna

Autoimmune gastritis (AIG) is characterized by a low-symptomatic course (85.0%). More than half of the patients are diagnosed with autoimmune thyroiditis (AIT), anemia of various origins, latent deficiency of iron and vitamin B12. Patients with AIG in Siberia are often infected with Helicobacter pylori (H. pylori) (47%), and in half of the cases with a cytotoxic CagA + strain, with a more frequent development of anemia compared to H. pylori-negative patients with AIG (64.7% vs. 3%, p=0.02). The levels of atrophy biomarkers measured using two test systems ("GastroPanel" and "GastroScreen-3") for the serological diagnosis of the autoimmune phenotype of fundal atrophic gastritis were determined, with the identification of the closest associations for the indicators "GastroScreen-3". So, noninvasive diagnostics of AIG using biomarkers of atrophy, including the test system "GastroScreen-3", is promising for detecting the early stages of the disease, before the development of vitamin B12 deficiency and pernicious anemia.

Keywords:autoimmune gastritis, Helicobacter pylori, «GastroPanel», «GastroScreen-3», atrophy biomarkers, anemia.