Laboratory diagnostics of the thyroid status of a pregnant woman as a parameter of thyroid pathology

Vinogradova Olga Pavlovna, Rakhmatullov Fagim Kasymovich, Ostanin Maxim Aleksandrovich, Levashova Olga Anatolyevna

This article discusses laboratory diagnostics of the thyroid status of a pregnant woman with further detection of thyroid pathology for the purpose of timely hormonal correction. To diagnose thyroid function in women during pregnancy, the serum levels of TSH, free thyroxine (svT4) and antibodies to TPO were determined. Evaluation of thyroid status was determined by enzyme immunoassay. The revealed pathology of the thyroid gland in pregnant women was evaluated: subclinical hypothyroidism, gestational hypothyroidism and manifest hypothyroidism were revealed. The urgency of the problem of diagnosis and treatment of hypothyroidism in women of reproductive age is determined by the high frequency of obstetric and perinatal complications, since a decrease in thyroid function plays an important role. Thyroid hormone therapy significantly improves both the course of pregnancy itself and its outcomes. Since the carriage of antibodies to TPO is a factor that reduces the normal functional reaction of the thyroid gland, necessary for the adequate development of pregnancy, in any disorders of reproductive function (miscarriage, infertility), timely assessment of thyroid function and determination of antibodies to TPO is necessary, and the onset of pregnancy in women with thyroid pathology requires adequate hormone therapy.

Keywords:pregnancy, thyroid dysfunction, pregnancy outcomes, autoimmune processes, thyroid hormones.