Vitamin D status in Parkinsons disese patients: assocuation with clinical features and dopamin

Gumenyuk Lesya Nikolaevna, Aslalieva Madina Shamilovna, Abalduev Viktor Mikhailovich, Kopylova Alexandra Vladimirovna, Li Ekaterina, Khudyakova Anastasia Sergeevna

Parkinson's disease (PD) is a severe socially significant progressive neurodegenerative disease. Evidence of a link between PD and the provision of the body with vitamin D is insufficient, which indicates the need for additional research in this direction. The aim of the study was to evaluate the association of vitamin D status in patients with PD with the clinical characteristics of the disease and the level of dopamine in the blood serum. The study involved 126 patients with idiopathic PD and 90 healthy volunteers (control group). Plasma levels of 25(OH)D and dopamine were assessed. It was found that in patients with PD, compared with the control, the level of 25(OH)D in the blood serum was statistically significantly lower. The association of the 25(OH)D level with the stage of the disease, the severity of non-motor and motor symptoms, the total UPDRS score, and the level of dopamine in the blood plasma was revealed. The data of this study provide additional evidence for a significant role of vitamin D in the pathophysiology of PD, which indicates the need for monitoring the level of 25 (OH)D in this population as a potential biomarker of disease progression.

Keywords:Parkinson's disease, vitamin D, motor and non-motor symptoms, dopamine.