Galimova Elvira Mansurovna (Ph.D., Associate Professor of the Federal State Budgetary
Educational Institution of Higher Education
Bashkir State Pedagogical University named after M. Akmulla (Ufa)
)
Galikeeva Guzel Fanilevna (Ph.D., Associate Professor of the Federal State Budgetary
Educational Institution of Higher Education
Bashkir State Pedagogical University named after M. Akmulla (Ufa)
)
Galimov Azat Musavirovich (Senior Lecturer, Ufa State Oil Technical University (Ufa))
Batrshina Rinata Ilshatovna (Master student, Bashkir State Pedagogical University
named after M.Akmulla (Ufa)
)
Mustafina Svetlana Radmirovna (Master student, Bashkir State Pedagogical University
named after M.Akmulla (Ufa)
)
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In this work, we studied the dynamics of changes in the cytokine profile of pro- and anti-inflammatory series (IL-1β, IL1RA, IL2, IL4, IL-6, IL10, α-TNF and CRP) under: activation of whole blood cells by a mitogen ex vivo and the action of a plant immunomodulator origin of "Echinacea" in healthy individuals with different genetic status for the genes of the family of cytokines interleukin-1 (IL-1β (rs1143634), IL1RA(VNTR in intron 2), IL1R1(rs2287047).
Among the examined individuals were identified with better responsiveness to the immunomodulator, which are carriers of combinations of genotypes of the interleukin-1 family (IL-1β (rs1143634), IL1Ra (VNTR), IL1RI (rs2287047): СС//I/I//TT, СС//I /II/TT, СT//I/II/TC.
An effective response to immunomodulation is provided by the genetically determined well-coordinated work of the cytokine-antagonist-receptor system for cytokines of the interleukin-1 family, which determines the correct launch of the cytokine cascade.
Keywords: cytokines, mitogen induction, immunomodulator, genetic polymorphism, immune response
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Citation link:
Galimova E. M., Galikeeva G. F., Galimov A. M., Batrshina R. I., Mustafina S. R. STUDY OF RESPONSIBILITY TO THE EFFECT OF AN IMMUNOMODULATOR OF PLANT ORIGIN IN PERSONS WITH DIFFERENT GENETIC STATUS ON THE GENES OF THE INTERLEUKIN-1 FAMILY // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№01. -С. 13-16 DOI 10.37882/2223–2966.2023.01.09 |
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