FEATURES OF THE COURSE OF THE BONE MARROW FORM OF ACUTE RADIATION SICKNESS AND ACUTE CYTOTOXIC SYNDROME IN MICE

Kokaya Georgy Nikolaevich, Kokaya Anna Alexandrovna, Zatsepin Viktor Viktorovich, Mukhina Irina Vasilyevna, Mavrenkov Eduard Mikhailovich

Single exposure to X-ray radiation at doses of 6.5, 7.5 and 8.0 Gy and intraperitoneal administration of cyclophosphane at doses of 500, 750 and 1000 mg / kg leads to the rapid development of the bone marrow form of acute radiation sickness and cytotoxic syndrome, accompanied by high mortality. After a single X-ray irradiation with a dose of 6.5 Gy and the administration of cyclophosphane at a dose of 500 mg / kg, the mortality rate for 30 days was 60.0 and 53.3%. As a result of exposure to X-ray radiation at doses of 7.5 and 8 Gy, as well as after a single administration of cyclophosphane 750 and 1000 mg / kg, mass death of mice was observed from 6 days and by 14 days the mortality rate reached 93.3 and 100%, while no differences in mortality and general functional status were found in mice. In the experimental groups, a decrease in the tala mass of mice was observed by more than 1.5 times when compared with the initial values and by more than 2 times when compared with the control groups. The dull and dirty color of the coat, signs of loose stools and allopecia, a decrease and absence of tentative research reactions, general motor activity up to the loss of posture testified to the acute cytotoxic effect of ionizing radiation and cyclophosphane. The absence of differences in the clinical course and mortality rates of the bone marrow form of acute radiation sickness and acute cytotoxic syndrome caused by cyclophosphane allows us to consider these experimental models interchangeable.

Keywords:experimental modeling, ionizing radiation, acute radiation sickness, cyclophosphane, cytotoxicity