Bebyakova Natalya Aleksandrovna (Doctor of Biological Sciences, Professor,
Northern State Medical University (Arkhangelsk)
)
Levitsky Sergey Nikolaevich (Candidate of Biological Sciences, Associate Professor,
Northern State Medical University (Arkhangelsk)
)
Shabalina Irina Alekseevna (Candidate of Biological Sciences, Associate Professor,
Northern State Medical University (Arkhangelsk)
)
Zhibort Ekaterina Leonidovna (Candidate of Biological Sciences, Associate Professor,
Northern State Medical University (Arkhangelsk)
)
Nikonova Yulia Mikhailovna (Candidate of Biological Sciences, Associate Professor,
Northern State Medical University (Arkhangelsk)
)
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The aim of this study was to investigate the involvement of EDNRA gene polymorphism (rs 6842241) (substitution of C for A) in the changes of cardiovascular system functioning in the young population living in the territory of the European North (Arkhangelsk region). It was found that the presence of polymorphic allele A led to changes in the levels of the main vasoactive endothelial factors nitric oxide (NO) and endothelin-1 (EDN1). The rs 6842241 polymorphism caused tendencies to changes in both the central hemodynamic indices and the indices of its reserve capacity, indicating its possible involvement in the formation of adaptive (maladaptive) reactions to the body's stress reactions.
Keywords:endothelin receptors, cardiovascular system, vasoconstrictor response, EDNRA gene polymorphism (rs 6842241)
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Read the full article …
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Citation link:
Bebyakova N. A., Levitsky S. N., Shabalina I. A., Zhibort E. L., Nikonova Y. M. INVOLVEMENT OF ENDOTHELIN-1 A-TYPE RECEPTOR (EDNRA) GENE POLYMORPHISM RS 6842241 IN CHANGES IN CARDIOVASCULAR SYSTEM FUNCTIONING IN EUROPEAN NORTH RESIDENTS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№05. -С. 16-20 DOI 10.37882/2223-2966.2023.05.06 |
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