DIFFERENTIAL DIAGNOSIS OF ANEMIA IN PATIENTS WITH HEPATITIS AND CIRRHOSIS OF THE LIVER: FROM LABORATORY CRITERIA TO THE POSSIBILITIES OF CONTRAST-FREE ASL PERFUSION

Telesh A., Morozova T.

Potentials of assessment of ASL-perfusion for the type of anemia (iron deficiency anemia and anemia of chronic diseases) prediction in patients with diffuse liver diseases (DLD) and microcytic hypochromic anemia were evaluated through the analysis of laboratory data, results of liver ASL-perfusion. It was established that inclusion of liver contrast-free ASL-perfusion in the examination algorithm may be useful for the differential diagnosis of anemia in this category of patients. In patients with DLD and microcytic hypochromic anemia, iron deficiency anemia should be suspected at HBF 102 – 109 ml/ 100g/min, anemia of chronic diseases in these patients should be suspected at HBF from 82 to 101 ml/100g/min. The ASL-perfusion technique demonstrated sensitivity – 0.9, specificity – 0.75 in the differential diagnosis of anemia in this category of patients.

Keywords:diffuse liver diseases, iron deficiency anemia, anemia of chronic diseases, magnetic resonance imaging, non-contrast ASL-perfusion of the liver