FEATURES OF THE DEVELOPMENT OF ENDEMIC GOITER IN RESIDENTS OF THE COASTAL REGIONS OF THE MAGADAN REGION

Pokhilyuk Natalya V., Gorbachev Anatoly L., Kirichuk Anatoly A.

The work is devoted to the study of the mechanisms of the formation of endemic goiter in coastal areas. The inhabitants of endemic goiter coastal territories of the Magadan region were studied. The content of iodine and selenium in various ethno-demographic groups (natives, mestizos, alien population) was determined by the methods of ioduria and spectral analysis of hair. It was shown that the territory of the coastal region (the city of Magadan) is free from iodine deficiency: the median of iodine in residents was 133.8 µg/l, with the lower limit of the norm being 100 µg/l. The level of iodine in the hair of residents was also within the reference values. However, the content of selenium, one of the key elements of thyroid synthesis in the inhabitants of the region, turned out to be lower than the recommended values, which may be a goiter factor. Severe iodine deficiency was found in ethnic aborigines living in the coastal area. Moreover, in the hair of the natives, the content of iodine and selenium was within the normal range. At the same time, no pronounced goiter was found in the natives. It has been suggested that reduced ioduria can be considered as an evolutionary mechanism for maintaining iodine in the body and maintaining thyroid function. This mechanism, through an adequate level of thyroid hormones, ensures the basic metabolism and heat production in aborigines in the conditions of the North.

Keywords:North, ethno-demographic groups iodine, iodine deficiency, selenium, thyroid gland