THE INVESTIGATION OF THE INTENSITY OF THE PROCESS OF LIPID PEROXIDATION IN THE ORAL FLUID IN DISEASES OF THE HARD TISSUES OF THE TEETH AND PERIODONTIUM

Tishkov Denis Sergeevich, Grigorieva Tatyana Mihailovna, Zabolotnyaya Arina Nikolaevna

This investigation is based on the determination the intensity of the process of lipid peroxidation in groups of patients with dental diseases (caries, gingivitis), totaling 70 subjects. The aim of the study is to compare the intensity of lipid peroxidation in the oral fluid in the norm and in the listed pathologies based on an experimental investigation of the oral fluid by the chemiluminescent method used. The study of the listed processes in the oral fluid is a poorly covered aspect in the scientific literature and has a direct applied value, which determines the relevance of this study. The study of the unique biochemical properties of the oral fluid makes it possible to develop and apply new minimally invasive diagnostic approaches, and also makes it possible to comprehensively assess the effectiveness of treatment and the metabolic state of a patient with dental pathology. In addition, changes in the level of lipid peroxidation can be used as a criterion for assessing the adequacy of preventive and therapeutic approaches aimed at reducing the intensity of redox reactions and neutralizing the toxicity of lipid peroxidation products (LPO). The study revealed the relationship between the prevalence of dental pathology and LPO intensity indicators, as well as the effect of general somatic pathologies and smoking on the level of peroxidation.

Keywords:lipid peroxidation, dental caries, gingivitis, antioxidant protection, oral fluid, chemiluminescence