RELEVANCE OF THE INTERACTION OF BACTERIAL INFECTION AND CANCER

Chertkoeva Maya Givievna, Gasarova Aminat Ruslanovna, Munaeva Mata Ramzanovna, Karimov Kazbek Olegovich, Aliyeva Aytaj Rafigkyzy, Usmanova Maryam Lom-Alievna

Bacterial infections are often found in the etiology of human diseases due to the ubiquity of bacteria. Such infections contribute to the development of periodontal disease, bacterial pneumonia, typhoid fever, acute gastroenteritis, and diarrhea in susceptible hosts. These diseases can be managed with antibiotics/antimicrobial therapy in some hosts. However, other hosts may not be able to eliminate the bacteria, allowing them to persist for long periods of time and greatly increase the host's risk of developing cancer over time. Indeed, infectious pathogens are modifiable risk factors for cancer, and in this comprehensive review, we highlight the complex relationship between bacterial infections and the development of several types of cancer. Here, we describe how bacterial surface fragments, bacterial protein toxins, and bacterial effector proteins can induce host cell DNA damage and thus can interfere with important host cell signaling pathways involved in cell proliferation, apoptosis, differentiation, and immune signal transmission.

Keywords:bacteria, cancer, fragments, antibiotics, infectious pathogens.