IMPACT OF MUTATIONS IN NEW SARS-COV-2 STRAINS ON THE PATHOGENICITY AND SPREAD OF COVID-19

Chertkoeva Maya Givievna

In 2020, the world is facing a global Covid-19 pandemic caused by the SARS-CoV-2 virus. During this time, the virus has undergone many mutations, leading to the appearance of various strains. COVID-19 caused by the SARS-CoV-2 coronavirus has become a global pandemic, it is extremely important to study the pathological changes caused by this virus. A comparative analysis of the literature has shown that clinical and morphological changes in internal organs in COVID-19 have some similarities and differences in Russia and abroad. According to research data, pathological changes in the lungs are the main sign of COVID-19 in both cases. Characteristic morphological changes in the lungs include diffuse damage to alveolar structures, the formation of hyaline membranes, fibrosis and thrombosis of small vessels. Thus, the new coronavirus infection is characterized by high transmissibility, rapid transmission of the virus from one patient to those in contact with him. In this regard, the rate of increase in incidence remains the subject of special attention and research aimed at identifying factors, including the impact of mutations in new strains of SARS-CoV-2, that may influence the pathogenicity and spread of Covid-19. Several years after the global SARS epidemic, the current SARS-CoV-2/COVID-19 pandemic has served as a reminder of how new pathogens can quickly emerge and spread through populations and ultimately cause serious public health crises. Prevention and surveillance programs play a key role in controlling infections of all kinds.

Keywords:Respiratory viral infection, pathogenicity, SARS-CoV-2, virology, microbiology