ANALYSIS OF THE PREVALENCE OF ADHESION FACTORS IN CORYNEBACTERIUM NON DIPHTHERIAE STRAINS

Kulshan Tatiana Alekseevna, Bugaeva Irina Olegovna

Currently, various species of Corynebacterium non diphtheriae cause multiple infectious complications and are resistant to a large arsenal of antimicrobial drugs. Obviously, their acquisition of pathogenicity and virulence factors is a key moment in enhancing their pathogenic potential. Analysis of the prevalence of adhesion factors in the structure of Corynebacterium non diphtheriae strains, which allow them to acquire new pathogenic properties in the process of evolution, contributes to understanding the mechanisms of their attachment to various target cells of the macroorganism and the development of more effective therapeutic and prophylactic drugs that prevent the adhesion of bacterial pathogens. In this regard, using the blastp algorithm, the amino acid sequences SpaA, SpaD and SpaH of the reference strain Corynebacterium diphtheriae NCTC 13129, which mediate bacterial adhesion, were examined for the presence of these homologous sequences in other species of Corynebacteria. It has been established that the SpaD and SpaH protein sequences are present in the structure of many species of Corynebacterium non diphtheriae, which play a different role in human infectious pathology.

Keywords:Corynebacterium non diphtheriae, genomes, proteins, adhesion factors, pili, pathogenic and virulent properties