SOLVING THE PROBLEMS OF TISSUE ENGINEERING AS ONE OF THE WAYS TO INCREASE LIFE EXPECTANCY

Feschenko D., Feschenko A., Verezubova N.

Tissue engineering is a promising area of medicine, which consists in the development and cultivation of cell populations that can replace damaged human tissues or diseased organs. Growing large populations of cells is a functionally difficult process that requires resolving contradictions at the molecular level. Differentiated cells have limited replicative potential because of multiple mitotic division and approaching the Hayflick limit. It would seem that bypassing the limit and removing restrictions can be a solution to the problem, but such "cellular immortality" is more likely to entail malignant cell degeneration. The article highlights the problems of tissue engineering, as well as the current state of research in this field.

Keywords:tissue engineering, replicative potential, Hayflick limit, carcinogenesis, telomerase, biomaterials