Ashirov Osman Vildan-oglu (Crimean Federal University named after. V. I. Vernadsky (Simferopol))
Storojeva Valeria Maksimovna (Crimean Federal University named after. V. I. Vernadsky (Simferopol))
Garkusha Nikita Olegovich (Crimean Federal University named after. V. I. Vernadsky (Simferopol))
Gorokhova Alexandra Vladimirovna (Crimean Federal University named after. V. I. Vernadsky (Simferopol))
Ivakhnenko Polina Igorevna (Crimean Federal University named after. V. I. Vernadsky (Simferopol))
Kaliberdenko Vitalii Borisovich (Candidate of Medical Sciences, Associate Professor of the Department of Internal Medicine No. 2 of the Order of the Red Banner of Labor of the Medical Institute named after. S.I. Georgievsky.
Crimean Federal University named after. V. I. Vernadsky (Simferopol)
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Hematologic malignancies, which have become increasingly common and present a variety of clinical and molecular features, pose challenges in treatment and prognosis. Epigenetic regulation, including mutations associated with DNA methylation, plays a key role in these processes. Hypomethylating agents and histone deacetylase inhibitors are effective in the treatment of some forms of leukemia and lymphoma. The review examines the factors responsible for DNA methylation.
Keywords:epigenetics, hematopoiesis, methylation, hemoblastosis, leukemia
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Citation link:
Ashirov O. V., Storojeva V. M., Garkusha N. O., Gorokhova A. V., Ivakhnenko P. I., Kaliberdenko V. B. EPIGENETIC REGULATION AND DNMT3A MUTATIONS: IMPACT ON THE DEVELOPMENT AND PROGNOSIS OF HEMATOLOGICAL MALIGNANTS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№02. -С. 133-138 DOI 10.37882/2223-2966.2024.02.04 |
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