Vanina D. S. (assistant,
Ryazan State Medical University named after academician I.P. Pavlov
)
Sychev I. A. (Doctor of Biological Sciences, Associate Professor,
Ryazan State Medical University named after Academician I.P. Pavlov
)
Byalovsky Yu. Yu. (Doctor of Medical Sciences, Professor,
Ryazan State Medical University named after academician I.P. Pavlov
)
Laksaeva E. A. (Candidate of Biological Sciences, Associate Professor,
Ryazan State Medical University named after Academician I.P. Pavlov
)
Kosova Yu. D. (Senior lecturer,
Ryazan State Medical University named after Academician I.P. Pavlov
)
Kokina D. G. (Senior lecturer,
Ryazan State Medical Universitynamed after Academician I.P. Pavlov
)
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hematopoiesis disorder is a serious side effect of metal salts, in particular lead, and drugs that stimulate hematopoiesis are very important for reducing the effects of hematopoiesis disorders. There is a number of convincing evidence of the positive effect of plant polysaccharides on the restoration of hematopoietic function of the bone marrow in lead toxic anemia. It has been established that the polysaccharide of calendula flowers, when introduced into the body of healthy animals, stimulates the processes of hematopoiesis. Additional studies are needed to assess the effect of polysaccharide on hematopoiesis in conditions of anemia. In our work, we studied the effect of a 5% aqueous solution of calendula flower polysaccharide administered intragastrically at a dose of 0.1 g/kg of body weight daily 1 time per day on hematopoiesis damage in rats induced by a 10% solution of lead acetate at a dose of 0.6 mg/kg and the underlying mechanisms. Our data show that calendula flower polysaccharide restores the number of erythroblastic islets in the bone marrow of rats with anemia on day 5 of the experiment, and on day 7 of the experiment leads to an increase in the number of erythroblastic islets by 14.63% compared with the control. The protective effect of the polysaccharide is to increase the number of red blood cells and hemoglobin to the control level on the 10th day of the experiment. The action of the polysaccharide normalizes the work of the catalase enzyme and the catalase number in animals with anemia on the 7th day of the experiment. The results showed that calendula flower polysaccharide can affect blood cells and bone marrow cells in vivo and thus demonstrated good potential and practical value for the treatment of hematopoiesis damage caused by lead acetic acid.
Keywords:calendula flower polysaccharide; hematopoiesis lesion; erythrocytes; anemia; erythroblastic islets
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Citation link:
Vanina D. S., Sychev I. A., Byalovsky Y. Y., Laksaeva E. A., Kosova Y. D., Kokina D. G. THE EFFECT OF CALENDULA FLOWER POLYSACCHARIDE ON ANIMALS WITH LEAD-ACETIC ACID ANEMIA // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№03/2. -С. 10-16 DOI 10.37882/2223-2966.2024.3-2.04 |
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