FEATURES OF THE VAGINAL MICROBIOTA IN PREGNANT WOMEN WITH CERVICAL INCOMPETENCE

Batomunkuev Ayur Ochirovich

Up to 24-30% of premature births are associated with cervical incompetence. Given the relevance of this problem, the pathogenesis of cervical incompetence is currently being actively studied. Potential mechanisms by which bacterial infections affect the cervix are mainly associated with matrix metalloproteinases. The ability of bacteria to secrete or induce metalloproteinases and destroy collagen and change the structure of connective tissue leads to premature remodeling of the cervix and weakening of the membranes. However, the mechanism leading to preterm birth is still unknown. The review includes data from domestic and foreign publications presented in the PubMed and RSCI databases. The role of vaginal microbiota in the pathogenesis of cervical incompetence is highlighted. Data from modern studies of the vaginal microbiota in pregnant women with a short cervix are presented, including a study of the effect of methods for correcting cervical incompetence on the microbiocenosis.

Keywords:microbiota, cervical incompetence, review