THE EFFECT OF PRENATAL EXPOSURE TO LEAD ACETATE ON THE STRUCTURE OF THE CEREBRAL CORTEX AND THE CONCENTRATION OF MALONDIALDEHYDE IN THE PERIPHERAL BLOOD OF 20-DAY-OLD DESCENDANT RATS

Komusova O. I., Kirdyashkina O. V., Gromova E. V.

The aim of the work is a comparative study of the effect of prenatal exposure to lead acetate on the structure of the cerebral cortex and the concentration of MDA (malondialdehyde) in the peripheral blood of 20-day-old descendant rats. The study was conducted on 90 mongrel white rats – in the offspring of 20 females who received 45 mg/kg of lead acetate solution as a source of drinking throughout pregnancy. The cortex and peripheral blood were studied on day 20 using histological, biochemical, morphometric and statistical methods. Changes in the thickness of layers and sizes of neuronal bodies on day 20, a decrease in the number of normochromic neurons, the appearance of destructively altered neurons, shadow cells, a decrease in the total numerical density of neurons and an increase in MDA in blood serum were revealed.

Keywords:neurons, shadow cells, peripheral blood, lead intoxication, terminal brain, malondialdehyde