EFFECTS OF PRENATAL EXPOSURE TO ELECTROMAGNETIC FIELD ON THE OXIDANT-ANTIOXIDANT SYSTEM IN RATS

Guliyeva Aynur Teymur, Abbasova Mushgunaz Tahir, Gadzhiev Ahmad Mahammad

The article presents data on changes in the level of lipid peroxidation (POL) product malondialdehyde (MDA) and the activity of catalase and superoxide dismutase enzymes in blood of 20- and 30-day-old rats exposed in utero to 460 MHz electromagnetic field in different periods of prenatal development. In 20-day-old rats, it has been shown that MDA level in erythrocytes is reduced for EMF exposure in the embryonic and prefetal periods, on the contrary, it is increased for exposition in fetal period. As for the activity of antioxidant enzymes, if irradiation in the embryonic period of development leads to an increase in the basic activity of both catalase and superoxide dismutase, then during irradiation in subsequent periods, a wavy nature of changes in activity is observed. So, if there is a slight increase in activity for SOD during the prefetal period of irradiation, then for catalase activity there is a significant decrease in activity during irradiation in the fetal period. Although by the age of 30 days in rats, the level of MDA in the blood shows a slightly elevated level when irradiated in all 3 periods of prenatal life, catalase activity is excessive for cases with irradiation in the embryonic and prefetal periods, while SOD activity is deficient for the prefetal period exposure. The observation of increased LPO activity and disturbances in the balance of antioxidant protection in blood under the influence of an ultra-high frequency electromagnetic field can be considered as a manifestation of prenatal stress syndrome. The corresponding changes in erythrocytes in early ontogenesis may be due to the relative immaturity of individual components of the enzymatic antioxidant system. The obtained data can be useful in studies of mechanisms of adaptation to changes in the external environment and possible causes of a number of hemolytic conditions in young children.

Keywords:electromagnetic field, rats, prenatal development, catalase, superoxide dismutase.