CLINICAL CASE. PREGNANCY IN A PATIENT WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: DIAGNOSIS AND MANAGEMENT TACTICS

Grigoryan Narine Arazikovna, Sargsyan Julietta Gurgenovna, Smolyanitskaya Anna Igorevna

Paroxysmal nocturnal hemoglobinuria is included in the list of orphan blood diseases. It is a rare acquired clonal disease of the blood system characterized by intravascular hemolysis, bone marrow dysfunction and an increased risk of thrombotic and organ complications. Pregnancy with paroxysmal nocturnal hemoglobinuria is undesirable due to the increased threat of miscarriage, premature birth, life and health of a woman. Using the case history of a patient with paroxysmal nocturnal hemoglobinuria (APG) as an example, we decided to show the features of the clinical picture of this disease and demonstrate the effectiveness of long-term pathogenetic treatment in pregnancy with a favorable outcome.

Keywords:Paroxysmal nocturnal hemoglobinuria (APG), pathogenetic treatment, pregnancy.