MICROBIOLOGICAL DISORDERS IN HELMINTHIASIS

Plieva Aishet Aagomedovna, Dzarmotova Zalina Issaevna, Dudarova Khadishat Yusupovna, Temirkeeva Yasmina Magomedovna

The increase in the number of non-communicable chronic diseases, in particular allergic, autoimmune and oncological ones, has led to the relevance of scientific research on various mechanisms of population immunity. Minimizing the influence of microbiotic communities (helminths) on the host's holistic immune system due to improved hygiene conditions in developed world powers is considered as a key risk factor for the formation and further development of non-communicable chronic diseases. Scientific studies have shown that both intestinal parasites and parasite waste products modulate the body's immune response. An increase in the concentration of gastrointestinal bacteria with anti-inflammatory properties can be identified as a pathogenetic mechanism of such modulation. Due to the emergence of modern technologies and methods of identification of microorganisms, it has become possible to significantly expand knowledge about the microbiota in various pathologies. Today, the analysis of microbiota modification in the digestive tract of the host organism is an urgent task. Solving this problem opens up new opportunities in the diagnosis, prevention and monitoring of allergic and intestinal diseases. The scientific significance is determined by the fact that, based on the hypothesis of ‘old friends’, helminths and microbiota, which coexisted with humans throughout evolution, have been determined to be important in the regulation of individual immunity. The research methodology is determined by determining the composition of the body's microflora. The purpose of the study is to present an expanded analysis of modern epidemiological and experimental studies in the field of evaluating the symbiosis of helminthic invasions and the microbiota of the digestive tract in order to identify possible mechanisms and tools for the prevention of non-communicable chronic diseases. Results and conclusions: it was determined that the reduction in the prevalence of helminthiasis in the population is the most important risk factor (threat) for the development of chronic non-communicable diseases. Experimental and epidemiological studies have confirmed the special importance of helminths in regulating the immune response in children, minimizing activity in autoimmune (allergic) inflammatory diseases. In our opinion, there are broad prospects for the development of qualitatively new therapeutic and preventive strategies in relation to non-communicable chronic diseases.

Keywords:microbial flora, enterobiosis, ascariasis, helminths, microecological equilibrium, disorders of intestinal biocenosis