PREDICTORS OF THE DEVELOPMENT OF TUMOR-ASSOCIATED STRUCTURAL EPILEPSY. CONTRIBUTION OF THE PERITUMORAL ZONE (PTZ) TO THE CREATION OF THE EPILEPTIC NETWORK

Shchavinskaya Asya Valer'evna

On average, about 25-60% of patients with intracranial tumors may have structural epilepsy [12], while the frequency of its manifestation varies due to different histological types of tumors. Peritumoral zone, previously studied mainly in the context of searching for new therapeutic options for high-grade gliomas (HGG), plays an important role not only in a number of oncological aspects of the disease, but also in the creation and maintenance of an epileptic network. Recent observations obtained during intracranial electrocorticography (ECoG) in patients with gliomas have shown that the areas of onset of seizures are often located 1.5 cm outside the tumor (Mittal et al., 2016), convulsive activity comes from induced changes in these areas, not from the tumor itself, except of glioneuronal tumors, containing neuronal elements [10]. Understanding the effect of gliomas on the peritumoral environment will allow us to better understand the pathophysiology of the TAE and develop targeted therapeutic tactics.

Keywords:peritumoral zone (PTZ), epileptic network, tumor-assotiated epilepsy (TAE), gliomas, predictors of seizures.