UREA DISEASE PREVALENCE ESTIMATE IN PREGNANT WOMEN: META-ANALYSIS

Bagryantsev V. A.

Urea disease during pregnancy is a serious health problem and can have a negative impact on the well-being of both the expectant mother and the child. The treatment of this condition often requires the joint participation of an obstetrician-gynecologist, a doctor of functional diagnosis and a urologist. In addition, undesirable effects associated with the use of anesthesia, radiation, drugs and surgical interventions for both the mother and the child limit the possibility of using the full range of diagnostic and therapeutic methods used in non-pregnant women. The purpose of the study.Conduct a meta-analysis based on a systematic review of evidence to assess the incidence of urolithiasis in pregnant women. Material and methods. The search for literature sources was performed on bibliographic databases of eLibrary and PubMed (Medline), in accordance with the recommendations contained in the reporting for system reviews and meta-analyses (PRISMA), and the guidelines described in the Cochrane Manual. Data for were obtained from the results of 9 clinical studies conducted by different authors for 2018, 2019, 2020, 2021, 2022 and 2023 among 3,444 participants. The weighted average for continuous variables with 95% confidence interval and heterogeneity of data based on I2 value in percentage. Results. The prevalence of urolithiasis in pregnant women ranges from 30.189% (CI: 23.171-37.962) to 43.956% (CI: 38.787-49.224); from 35.109% (DI: 31.851 - 38.473) to 73.714% (DI: 66.539 - 80.068); from 15.531% (DI: 11.980 - 19.650) to 17.510% (DI: 13.068 - 22.719); from 26.904% (DI: 23.835 - 30.146) to 50.802% (DI: 43.407 - 58.172); and 24.299% (DI: 19.708-29.372), respectively. Ultimately, the effect of random factors showed different true values relative to the total average. Conclusion. The prevalence of urolithiasis among pregnant women ranges from 30.189% (CI: 23.171-37.962) to 26.904% (CI: 23.835-30.146), which is statistically significant and associated with the place of residence of the pregnant woman and depends on the impact of specific risk factors. The patterns identified are only the first step in a scientific study to study the prevalence of urolithiasis among pregnant women. Identification of risk factors will help to develop a program of preventive measures to prevent possible complications of this pathology and improve the health of pregnant women.

Keywords:pregnancy; urolithiasis; meta-analysis; prevalence; risk factors.