THE SIGNIFICANCE OF THE MICROSTRUCTURE CHARACTERISTICS OF THE CEREBRAL METASTASES’ PERITUMORAL ZONE (PTZ) IN THEIR COMPLEX TREATMENT

Shchavinskaya Asya Valer'evna

The metastatic cascade is a complex dynamic process of secondary tumor formation, at each stage of which many mechanisms are involved. Most often in clinical practice, specialists have to work on the second stage of metastasis, when metastatic cells have already colonized the brain, and the tumor focus is diagnosed using instrumental research methods. The area surrounding the tumor is a zone of surgical and therapeutic action to restrain the growth of the tumor focus.

Keywords:Metastatic cascade, mechanotransduction, blood–brain barrier (BBB), CNC-cancer crosstalk, metabolic reprogramming, immune-checkpoint inhibitor (ICIs), M1- and M2-microglia