D-DIMER DETERMINATION IN CLINICAL LABORATORY DIAGNOSIS OF CORONAVIRUS INFECTION

Bugero Nina Vladimirovna, Titova Anna Alexandrovna, Stepanova Sofia Sergeevna

Increased D-dimer levels correlate with the severity of COVID-19, indicating microthrombosis and thrombosis activation. It is associated with worse prognosis, respiratory and multi-organ failure. Coagulogram analysis of patients with COVID-19 revealed increased D-dimer, fibrinogen, prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating coagulation abnormalities. D-dimer levels correlated with the severity of the disease and lung damage. A study of patients at the Pskov Infectious Disease Hospital confirmed the association of elevated D-dimer with COVID-19 severity and mortality. It was found that biochemical parameters of hemostasis in patients with COVID-19 demonstrate a number of significant patterns. Thus, according to the data of the conducted study, out of the total number of 99 examined persons, in 39 patients with severe course of the disease the level of D-dimer exceeded the reference values in 6.5 times, which indicates the development of pronounced disorders in the blood coagulation system in patients with unfavorable prognosis of the course of a new coronavirus infection. Analysis of the comorbid background in the examined patients revealed the presence of chronic diseases of various organs and systems, including cardiovascular, cerebrovascular and respiratory, diabetes mellitus, obesity, malignant tumors, chronic diseases of the hepatobiliary system and kidneys. Thus, D-dimer levels serve as a valuable prognostic marker of COVID-19 severity, allowing us to assess the risk of complications and poor outcome.

Keywords:COVID-19, comorbid pathologies, coagulation disorders, D-dimer.