ASSESSMENT OF DEGENERATIVE CHANGES IN CELLS DURING INFECTION WITH EPSTEIN-BARR VIRUS

Lifenko K. O., Otrishko M. P.

The purpose of the review is to analyze data on morphological changes in cells and histological structure of affected organs at different stages of infection with EBV infection. The review evaluates degenerative changes in Epstein-Barr virus infection using the example of infectious mononucleosis, as well as EBV, and provides opinions of immunologists regarding cytochemical changes during virus invasion. The high contagiousness of infectious mononucleosis, the presence of complications, as well as the high variability of EBV-associated complications in chronic infection have made the Epstein-Barr virus (EBV) significant not only for the pediatric community, but also for oncologists, gastroenterologists and other specialist doctors. In conclusion, a discussion is given regarding the analysis of clinical cases in which specific histological tissue changes in concomitant EBV infection are consecrated.

Keywords:Epstein-Barr virus, B-lymphocytes, infectious mononucleosis, IFN-γ, mixinfections, inflammatory bowel diseases, chronic inflammation