THE EFFECT OF SMOKING ON THE CONTENT OF α2- AND γ-GLOBULIN FRACTIONS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Agapova Yulia Rеfatovna, Strokovsky Grigory Semyonovich, Nazarova Victoria Alvidovna

Chronic obstructive pulmonary disease (COPD), being a chronic inflammatory disease, is reflected during the period of exacerbation in the content of protein fractions in the blood serum of patients. An increase in the level of the α2-globulin fraction is a positive marker of serum antiprotease activity as a protective reaction of the body to the action of tissue-damaging proteases at the height of inflammation. A decrease in the content of the gamma-globulin fraction in the late stages of COPD is a consequence of depletion of immunity against the background of a chronic inflammatory process. To prove the importance of antismoking measures, an assessment of the effect of smoking on the content of α2- and γ-globulin fractions and on the life prognosis in patients with exacerbation of COPD depending on smoking/non-smoking was carried out.

Keywords:chronic obstructive pulmonary disease, serum protein fractions, α2-globulins, γ-globulins, antiprotease activity, immunoglobulin deficiency.