PATHOGENESIS AND RISK FACTORS INFLUENCING THE DEVELOPMENT OF THROMBOEMBOLIC COMPLICATIONS IN PATIENTS WITH COVID-19

Bugero Nina Vladimirovna, Ilyina Natalya Anatolyevna, Povtoreyko Anastasia Viktorovna, Aleksandrova Svetlana Mikhailovna

SARS-CoV-2 infection causing COVID-19 may increase the risk of thrombosis in patients. The mechanisms of clotting activation in this viral infection are not yet fully understood, but have been hypothesized to be related to inflammatory reactions and systemic changes caused by the virus. Elevated D-dimer levels indicate abnormalities in the coagulation process and may be an indicator of the risk of thromboembolic complications. The results of this study showed that coagulation impairment in COVID-19 may not only lead to thrombotic complications but also exacerbate acute respiratory failure. A high correlation was found between SARS-CoV-2 infection and the incidence of venous thromboembolic complications. Elevated D-dimer values were associated with poor prognosis and high mortality. A positive high correlation between D-dimer levels and the degree of lung damage was found. D-dimer concentration increased as the course of COVID-19 became more severe.

Keywords:SARS-CoV-2 infection, thrombosis, coagulopathy, D-dimer, fibrinogen