Salikhova Miyasat Magomedalievna (MD, PhD, Associate Professor, Dagestan State Medical University of the Russian Ministry of Health, Makhachkala)
Budaichiev Gasan Magomed-Alievich (MD, PhD, Assistant, Dagestan State Medical University of the Russian Ministry of Health, Makhachkala)
Nabgouri Yunes (St. Petersburg State Budgetary Healthcare Institution City Polyclinic No. 3, St. Petersburg, Russia)
Bakhtiyarova Gulnaz (St. Petersburg State Budgetary Healthcare Institution City Polyclinic No. 3, St. Petersburg, Russia.)
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The article investigates the role of the bacterium Porphyromonas gingivalis in the pathogenesis of oral squamous cell carcinoma (OSCC). The study included 10 patients with OSCC, 5 with chronic periodontitis, and 5 healthy individuals. The presence of P. gingivalis was detected using PCR and FISH methods, and levels of inflammatory markers (IL-6, COX-2) and the proliferation marker (Ki-67) were assessed by immunocytochemistry. The results showed that the presence of P. gingivalis is associated with increased inflammatory activity and tumor cell proliferation, which worsens the disease prognosis. These findings underscore the significance of P. gingivalis as a potential therapeutic target in the treatment of OSCC.
Keywords:Porphyromonas gingivalis, oral squamous cell carcinoma, inflammatory markers, cell proliferation, FISH, PCR
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Citation link:
Salikhova M. M., Budaichiev G. M., Nabgouri Y. , Bakhtiyarova G. THE ROLE OF PORPHYROMONAS GINGIVALIS IN THE PATHOGENESIS OF ORAL SQUAMOUS CELL CARCINOMA // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№10/2. -С. 177-180 DOI 10.37882/2223-2966.2024.10-2.23 |
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