TRANSGENIC SYSTEMS FOR THE PRODUCTION OF AN "EDIBLE" VACCINE AGAINST HEPATITIS B VIRUS

Smirnova Ekaterina A., Ivannikova Regina F., Savinov Vasiliy A.

Edible vaccines represent a promising area of scientific research that is exploring the possibility of using edible plants or products to deliver vaccines and stimulate the immune system. Such vaccines can provide a simpler and more affordable form of immunization, eliminating the problems associated with expensive and complex vaccine delivery methods. One example is a vaccine aimed at the prevention of hepatitis B, which many scientists have been developing and researching almost from the very beginning of the practical implementation of the idea of producing various proteins by transgenic plants. Hepatitis B is a very common and dangerous viral infection. Every year, 50 million cases of acute hepatitis B alone are recorded in the world. In this article, a number of studies have been conducted that confirmed the possibility of expressing hepatitis B virus antigens in transgenic systems, based on research, the relevance of using plants such as tomatoes and the fungus Flammulina velutipes to produce an "edible" vaccine, as well as its immunogenicity for the body, has been proven.

Keywords:"edible" vaccines, oral vaccines, food biotechnology, transgenic plants, hepatitis B virus vaccine, hepatitis B surface antigen.