TO STUDY THE RELATIONSHIP BETWEEN HOMOCYSTEINE LEVELS AND THE SEVERITY OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME IN PATIENTS WITH ACUTE CORONARY SYNDROME

Sultanova Oksana Esedullayevna, Chernysheva Elena Nikolaevna, Tsverkunova Olga Vladimirovna, Karabasova Asel Sagyndykovna, Lorsnukaev Islam Ruslanovich, Magomedova Zarema Imanshapievna, Sultanova Samira Shamilevna

Cardiovascular diseases, including coronary heart disease, pose a serious threat to the health and life of people both in Russia and abroad. Acute coronary syndrome (ACS), including myocardial infarction and unstable angina, is the most common form of coronary heart disease and annually kills more than 15% of the population. It is important to note that hereditary factors such as undifferentiated connective tissue dysplasia syndrome can significantly increase the risk of developing cardiovascular diseases. Currently, traditional risk factors for cardiovascular diseases do not always take into account all possible complications, so the search for new markers that can more accurately predict risk is an urgent task. One of these markers is homocysteine (Hcy), which is an intermediate product of the metabolism of the amino acids methionine and cysteine. A high concentration of Hcy in the blood has a toxic effect on cells, contributes to the development of atherosclerosis and negatively affects the structure of the heart muscle. Based on contradictory data and insufficient knowledge of the problem, we formulated the purpose of the study, to study the presence of a correlation between the level of Hcy and the severity of the syndrome of undifferentiated connective tissue dysplasia. Research materials. Based on a careful selection of patients from 528, the study included 220 patients with ACS, of whom 113 had undifferentiated connective tissue dysplasia syndrome, 81 patients with undifferentiated connective tissue dysplasia syndrome without cardiovascular pathology and 50 somatically healthy individuals. The groups are comparable in age and gender. Research methods: physical, laboratory, instrumental, special research methods (enzyme immunoassay to determine the level of the following indicators: Hcy and to confirm the syndrome of undifferentiated connective tissue dysplasia, the level of human antibodies to type II and III collagens – oxyproline (OR)) was determined. Diagnosis of the syndrome of undifferentiated connective tissue dysplasia was carried out on the basis of a questionnaire by Elykomov V.A. and Kopylov A.N. (detection of 6 or more stigmas of dysembriogenesis). To conduct a statistical analysis of the data obtained, the following programs were used: IBM SPSS Statistics 28 and StatTech v. 3.1.8. During the study, the following results were obtained. Conclusion: During the correlation analysis, the following results were obtained: it was found that there was a very strong direct relationship between the level of Hcy and the content of OR in the ACS group with undifferentiated connective tissue dysplasia syndrome r = 0.93; p<0.001 and a direct link of average strength in the ACS group r = 0.74; p<0.001. When conducting a correlation analysis in the group with undifferentiated connective tissue dysplasia syndrome, direct strong significant links were established between Hcy and grade 3 dysplasia severity r = 0.88; and in the ACS group with undifferentiated connective tissue dysplasia syndrome, this link was direct significant very strong r = 0.93.

Keywords:acute coronary syndrome; connective tissue dysplasia; homocysteine; oxyproline