SERUM MARKER PROFILE IN DUAL CARDIAC PATHOLOGY: ARTERIAL HYPERTENSION AND CORONARY HEART DISEASE

Khokonova Tamara Muratovna, Kharaeva Zaira Feliksovna, Sokhrokova Naina Muratovna, Sokhrokova Disana Muratovna, Elbaeva Alina Dzhagafarovna

The aim of this work was to evaluate the concentrations of pro-inflammatory interleukin-1β, anti-inflammatory interleukin-10 and CD40 ligand in the serum of patients suffering from arterial hypertension (AH), coronary heart disease (CHD) and heart rhythm disorders (HRD). The study included a contingent of 100 patients (mean age was 57±10 years), divided into three clinical groups according to the indicated nosological forms. Complexes of instrumental methods of examination and quantitative determination of blood biomarkers by immunoenzyme analysis were applied during the work. The obtained results indicate a statistically significant role of inflammatory mediators in the pathogenetic mechanisms of cardiac arrhythmias formation, which significantly expands modern ideas about the etiopathogenesis of these conditions. A statistically significant increase in serum concentrations of IL-1β and CD40L in patients with diagnosed CHD was found, with the most pronounced deviations in individuals with concomitant rhythm disorders, which demonstrates the intensification of inflammatory reactions. The detected increase in IL-10 level indicates the presence of chronic systemic inflammatory process with involvement of endothelial component of the vascular wall, which can be considered as an indirect sign of atherosclerotic lesion of the vascular channel. Based on the obtained data, the concept of using the studied cytokines as potential diagnostic and prognostic markers was formulated, and the necessity to consider the revealed pathophysiological mechanisms when developing a strategy of complex pharmacotherapy of this category of patients was substantiated.

Keywords:coronary heart disease, arterial hypertension, heart failure, cardiosclerosis, NAG, TIMP1, proMMP1