Sheyko E. A. (Associate Professor of the Department of Microbiology, Virology and Immunology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky; V.I. Vernadsky Crimean Federal University; Simferopol)
Sataieva T. P. (Head of the Department of Microbiology, Virology and Immunology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky; V.I.
Vernadsky Crimean Federal University; Simferopol
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Smagliy N. N. (Assistant of microbiology, virology and immunology department, Order of the Red Banner of Labor Medical Institute S.I. Georgievsky KFU named after V.I.Vernadsky; Simferopol)
Reshetnik G. V. (Associate Professor of the Department of Microbiology, Virology and Immunology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky; V.I. Vernadsky Crimean Federal University; Simferopol)
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The use of bacteria and products based on them has a high potential among the immunotherapy of tumor diseases. Bacterial therapy for cancer can be used both as a monotherapy and in combination with other anti-tumour treatments to achieve high clinical outcomes. This review represents the main mechanisms of action on tumours by bacteria; the most significant results from pre-clinical trials of bacterial antitumour drugs; modern directions of the construction of bacterial strains as means of delivery of chemotherapy drugs in tumors. We also discuss how various non-pathogenic bacteria have been modified through genetic engineering to develop the ability to cause tumor regression, and prospects for bacterial antitumor therapy. It is concluded that the development of bacterial agents for cancer therapy is a promising direction of experimental oncology.
Keywords:cancer; bacterial therapy; cancer immunotherapy; bacteriotherapy; tumor-targeting bacteria; therapeutic bacteria
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Citation link:
Sheyko E. A., Sataieva T. P., Smagliy N. N., Reshetnik G. V. NON-PATHOGENIC BACTERIA IN ANTITUMOR THERAPY // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№05/2. -С. 29-32 DOI 10.37882/2223-2966.2025.05-2.30 |
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