CLINICAL AND LABORATORY FEATURES OF ACUTE POSTINFARCTION CARDIAC ANERVISM AND ITS FREQUENCY IN PATIENTS WITH ACUTE CORONARY SYNDROME ON THE BACKGROUND OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

Sultanova Oksana Esedullayevna, Chernysheva Elena Nikolaevna, Kasatkina Svetlana Grigorievna, Karabasova Assel Sagyndykovna, Deshiev Bislan Selimovich, Daudova Mukhminat Magomedovna

Cardiovascular diseases (CVD) continue to occupy a leading position in the structure of morbidity and mortality. The problem is global, causing significant damage to the health of the population and the socio-economic development of the Russian Federation as a whole. There is no doubt that the widespread prevalence of CVD is related to congenital pathology, which includes undifferentiated connective tissue dysplasia (UCTD) syndrome [1; 3]. According to many authors, UCTD is the background for the appearance and progression of heart and vascular pathology. One of the manifestations of the UCTD anomaly is vascular syndrome, which can be represented by idiopathic dilations of elastic arteries (aorta, pulmonary trunk, etc.); bifurcation - hemodynamic aneurysms [10; 11]. According to coronary angiography, the frequency of detection of coronary artery anomalies in the general population is 0.3 - 0.8% [1; 3; 11]. As for the "dysplastic heart", it is represented by the following changes in coronary vessels: topographic anomalies of the coronary arteries, "muscle bridges", aneurysms, ectasia, compression of the mouths of the coronary arteries by an aortic aneurysm, occlusion of the coronary arteries by the exfoliating aortic root [10; 11]. The aneurysmal changes in the coronary arteries considered by the authors, as a manifestation of UCTD, led to a sharp slowdown in coronary blood flow with possible increased thrombosis in conditions of plethoric syndrome (erythrocytosis, hyperhemoglobinemia, increased blood viscosity), which caused the development of acute coronary pathology [3; 10; 11]. Patients with UCTD are at high risk for the development of postinfarction aneurysms. A postinfarction aneurysm is a limited area of thinned scar or fibromuscular tissue with a protrusion of the heart wall of the damaged area. It is also an indisputable fact that clinical and laboratory changes are very often detected in patients with UCTD: low levels of magnesium (Mg) in the blood, high levels of homocysteine (Hcy) and oxyproline (OP) [4; 5; 9;12; 13].

Keywords:acute coronary syndrome, undifferentiated connective tissue dysplasia, aneurysm, homocysteine, magnesium, oxyproline.