ANALYSIS OF THE MICROBIAL POOL OF MYOMATOUS NODES AND ENDOMETRIUM IN PATIENTS WITH DIFFERENT CLINICAL VARIANTS OF UTERINE FIBROID COURSE IN MENOPAUSE

Guley Yulia Viktorovna, Sidorova Yulia Dmitrievna, Davidyan Liana Yuryevna

The aim of the study was to investigate the composition of the microbial pool of myomatous nodes and endometrium in postmenopausal women with different clinical variants of uterine fibroid course. A retrospective analysis of microbiological data was performed in 167 patients who underwent surgical treatment. The main group included 97 women with rapidly growing uterine fibroids, while the comparison group consisted of 70 patients in whom fibroids were an incidental finding. Microbiological examination was carried out using modern identification methods (MALDI-TOF MS, VITEK 2, WASP). It was found that in the main group, microbiota was predominantly represented by conditionally pathogenic microorganisms (Escherichia coli, Enterococcus faecalis, Staphylococcus epidermidis), with the frequency of microbial mixtures reaching 67.0% versus 12.9% in the comparison group (p<0.001). In myomatous nodes of the main group, microbial colonization was detected in 77.3% of cases, mainly E. coli and Bacteroides. The findings suggest a possible role of microbiota in the pathogenesis of rapid fibroid growth and highlight the need for further research.

Keywords:Uterine Fibroid; Menopause; Microbiota; Endometrium; Myomatous Node.