APPLICATION OF CLUSTER ANALYSIS TO PREDICT INTESTINAL PERISTALTIC INHIBITION BASED ON VIDEO RECORDING PERISTALSIS DATA IN LABORATORY ANIMALS

Chernyadyev Sergey Alexandrovich, Kubasov Kirill Alexandrovich, Zhilyakov Andrey Viktorovich, Borodikhina Valeria Anatolyevna, Sivkova Nadezhda Ivanovna

Introduction. Paresis and paralytic intestinal obstruction, which occur in the context of severe forms of peritonitis, represent a pressing issue in modern medicine, as they are a fairly common phenomenon after surgeries on abdominal organs and other types of surgery. The pathogenesis of paralytic intestinal obstruction is diverse and has various causes. Materials and Methods. The development of diffuse peritonitis was modeled in rabbits of the “White Giant” and “Gray Giant” breeds. The animals were divided into two groups (15 subjects in each): 1—experimental group, treated using electrical stimulation; 2—control group. The total observation period for the laboratory animals was 7 days. Results. Intestinal electrical stimulation is an effective treatment method only in cases of pronounced motility reduction observed in Cluster 0. For this group, the use of electrical stimulation has a significant therapeutic effect. In groups with moderate (Cluster 1) and minimal (Cluster 2) motility reduction, no statistically significant effect of electrical stimulation was identified. Conclusion. A comprehensive analysis of changes in peristaltic velocity combined with clinical manifestations (time to first stool and gas passage) provides a reliable basis for predicting the postoperative course and justifying the need for additional measures to combat enteric insufficiency in specific patients.

Keywords:paresis, paralytic intestinal obstruction, peritonitis