INTRAARTERIAL CISPLATIN ADMINISTRATION IN PATIENTS WITH ADVANCED MAXILLARY SINUS CARCINOMA. EFFICIENCY AND SAFETY

Zagorulko Alexey I., Nistratov Grigory P.

Squamous cell carcinoma of the maxillary sinus is often diagnosed at late stages. Surgical treatment remains the main method of cancer treatment, but it is associated with severe cosmetic defects and functional impairments. Intraarterial chemoinfusion makes it possible to reduce the size of the tumor, thereby avoiding such extensive operations. Administration of cisplatin intraarterially is an effective and safe method. Clinical positive dynamics is noted in the early postoperative period, in the form of a reduction in pain and edema, which allows the patient to reduce the amount of painkillers taken, improves breathing and swallowing, making it possible to eat more comfortably and, as a result, gain body weight. Three consecutive courses of therapy lead not only to clinical results, but also to instrumental ones, which is reflected in a decrease in the volume of the tumor, its microvascular invasion and structure as a whole. The clinical effect after the first course improves both the general and psychological condition of the patient, allows him to remain socially active, maintaining a positive attitude towards recovery, which plays a very important role in treatment. Thus, this technique is promising, effective and technically possible in many institutions of the country. Objective: to evaluate the safety and effectiveness of treatment of patients with inoperable maxillary sinus tumors by angiographic intraarterial administration of cisplatin.

Keywords:TACI, TACE, squamous cell carcinoma, maxillary sinus, cisplatin