Useinova Rean Khairievna (Federal State Autonomous Educational Institution of Higher Education "V.I. Vernadsky Crimean Federal University" Order of Red Banner of Labor S. I. Georgievsky Medical Institute, Simferopol)
Beloglazov Vladimir Alekseevich (Doctor of Medical Sciences, Professor,
Federal State Autonomous Educational Institution of Higher Education "V.I. Vernadsky Crimean Federal University" Order of Red Banner of Labor S. I. Georgievsky Medical Institute, Simferopol
)
Яцков Игорь Анатольевич (кандидат медицинских наук
Федеральное государственное автономное образовательное учреждение высшего образования «Крымский федеральный университет имени В.И. Вернадского» Ордена Трудового Красного Знамени Медицинский институт имени С. И. Георгиевского, г. Симферополь
)
Ageeva Elizaveta Sergeevna (Doctor of Medical Sciences, Professor,
Federal State Autonomous Educational Institution of Higher Education "Vernadsky Crimean Federal University" Order of Labor Red Banner Medical Institute named after S. I. Georgievsky, Simferopol
)
Repinskaya Irina Nikolaevna (Federal State Autonomous Educational Institution of Higher Education "Vernadsky Crimean Federal University" Order of Labor Red Banner Medical Institute named after S. I. Georgievsky, Simferopol)
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Chronic low-intensity inflammation plays a key role in the development of cardiovascular complications in patients with type 1 diabetes mellitus (DM1). However, data on the relationship between markers of systemic inflammation, such as highly sensitive C-reactive protein (hc-CRP), and parameters of structural remodeling of the left ventricular myocardium (LV) in this category of patients are significantly limited. The aim of the study was to evaluate the associations between the level of hf-CRP and the parameters of LV hypertrophy in patients with DM1. The study included 80 patients (32 men and 48 women) with a verified diagnosis of DM1 who were hospitalized in the endocrinology department of the Semashko RCB. The median age was 35 (23.0-42.35) full years. The patients underwent a study of biomaterial (blood plasma) using enzyme immunoassay (ELISA) to determine the level of C-reactive protein (mg/L), a comprehensive echocardiographic assessment of the parameters of left ventricular remodeling (LV) (LV myocardial mass index, interventricular septum thickness, LV posterior wall thickness False identity). The correlation analysis was performed using the Pearson correlation coefficient. Statistical processing of the obtained data was performed using the IBM SPSS Statistics 27 software package. A statistically significant positive correlation of average strength was found between the level of hf-CRP and LVEF (r = 0.530; p = 0.011), LVEF (r = 0.502; p = 0.017) and LVEF (r = 0.450; p = 0.035). The data suggest that an increased level of hf-CRP is associated with more pronounced LV myocardial hypertrophy. Systemic inflammation, assessed by the level of hf-CRP, may contribute to the development of LV remodeling and hypertrophy in patients with DM1. The results obtained reflect the potential role of anti-inflammatory strategies in the prevention of cardiac complications in DM1.
Keywords:diabetes mellitus, left ventricular remodeling, left ventricular myocardial mass index, C-reactive protein
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Citation link:
Useinova R. K., Beloglazov V. A., Яцков И. А., Ageeva E. S., Repinskaya I. N. ASSOCIATIONS OF LEFT VENTRICULAR REMODELING PARAMETERS AND HIGHLY SENSITIVE C-REACTIVE PROTEIN IN PATIENTS WITH TYPE 1 DIABETES MELLITUS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№10. -С. 301-306 DOI 10.37882/2223-2966.2025.10.42 |
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