Solovyova Natalya Gennadyevna (Ph.D. biol. sciences, head of the department of medical and biological foundations of physical education,
Belarusian State Pedagogical University named after Maxim Tank, Belarus, Minsk
)
Kasko Valentina Anatolyevna (Ph.D. vet. sciences, associate professor of the department of medical and biological foundations of physical education,
Belarusian State Pedagogical University named after Maxim Tank, Belarus, Minsk
)
Kobzev Vadim Fedorovich (Ph.D. med. sciences, associate professor of the department of medical and biological foundations of physical education,
Belarusian State Pedagogical University named after Maxim Tank, Belarus, Minsk
)
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The aim of the study was to identify the correlation between polymorphisms genes ACE, NOS3 and BDKRB2, which are among the key molecular genetic links in the functional capabilities of the cardiovascular system, with diagnostic indicators of its performance in athletes-wrestlers and the risk of circulatory disorders. The study involved athletes-wrestlers (n=49) of different weight categories and different levels of sportsmanship (MSMC–MS–KMS–I category), as well as clinically healthy individuals (n=50) who are not professionally involved in sports. The study assessed the frequency of polymorphisms genes ACE (rs4646994 Alu I/D), NOS3 (rs1799983 G894T; rs2070744 T786C) and BDKRB2 (−9/+9), analyzed the state of the cardiovascular system by a number of functional parameters and determined correlations. The results of a comprehensive analysis of the frequency of polymorphisms genes ACE, NOS3 and BDKRB2 in athletes-wrestlers, depending on weight categories and level of athletic qualifications, showed that genotypes ACE DD+NOS3 (894)GG+NOS3 (786)TT+BDKRB2 +9/+9 are more common in athletes-wrestlers of the high weight category of athletic qualifications. In contrast, polymorphisms genes of ACE ID+NOS3 (894)GG+NOS3 (786)TT+BDKRB2 −9/+9 predominate in athletes-wrestlers of low weight categories of sports qualifications (MSMC–MS). Аthletes-wrestlers of both hypersthenic and normosthenic physiques, but of a lower level of athletic qualification (KMS–I category), have no significant differences with the population occurrence of the studied genes. Polymorphic variants genes of the ACE, NOS3 and BDKRB2 have a high correlation with hemodynamic parameters (HR, BP, SV, HI, and blood circulation type; 0,751<r<1,0). Less advantageous variants of the "sports genes" are the combination ACE DD+NOS3 (894)TT+NOS3 (786)CC+BDKRB2 +9/+9, the carriage of which may be a risk factor for stress on the cardiovascular system, which must be taken into account during medical and pedagogical control and individualization of the training process.
Keywords:correlation, gene polymorphisms, cardiovascular system, circulatory system, sports genes
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Citation link:
Solovyova N. G., Kasko V. A., Kobzev V. F. CORRELATION OF POLYMORPHISMS GENES ACE, NOS3, BDKRB2 WITH FUNCTIONAL PARAMETERS OF THE CARDIOVASCULAR SYSTEM IN ATHLETES-WRESTLERS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№12. -С. 14-20 DOI 10.37882/2223-2966.2025.12.38 |
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