BETA-BLOCKERS AND ACUTE DECOMPENSATION OF HEART FAILURE: WITHDRAWAL EFFECTS, TREATMENT STRATEGY

Barkhatova Natalia Anatolyevna, Barkhatova Ekaterina Igorevna

Beta-blockers are used as part of the combination therapy for chronic heart failure. However, with the development of acute cardiac decompensation, discontinuation of these medications becomes necessary. This is accompanied by a number of clinically significant effects that can complicate the course and outcome of this pathology. A meta-analysis of the effects of beta-blocker discontinuation in acute decompensated heart failure was conducted based on the results of 2,142 clinical cases. The observed effects of beta-blocker discontinuation in ADHF, such as an increase in complications and the risk of mortality, indicate the need to maintain them in the combination treatment of this pathology and determine the need to resume beta-blocker therapy as soon as possible after the elimination of contraindications. The factors identified during the data analysis that reduce the risk of developing an adverse outcome in ADHF after beta-blocker discontinuation require the attention of clinicians and open up opportunities for further scientific research.

Keywords:acute decompensated heart failure, beta-blocker discontinuation.