Guliyeva Gunel Zakirkyzy (radiotherapist, A.F. Tsyba MRRC, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation)
Mkrtchyan Liana Sirekanovna (Doctor of Medical Sciences, A.F. Tsyba MRRC, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation)
Kucherov Valery Vladimirovich (Candidate of Medical Sciences, A.F. Tsyba MRRC, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation)
Krikunova Lyudmila Ivanovna (Doctor of Medical Sciences, Professor, A.F. Tsyba MRRC, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation)
Ivanov Sergey Anatolyevich (Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Director of the Medical Radiological Research Center named after A.F. Tsyb; Peoples' Friendship University of Russia )
Kaprin Andrey Dmitrievich (Doctor of Medical Sciences, Academician of the Russian Academy of Sciences,
General Director of the NMIC of Radiology of the Ministry of Health of the Russian Federation; Peoples' Friendship University of Russia; P.A. Herzen Moscow Institute of Medical Sciences – branch of the Federal State Budgetary Institution "NMIC of Radiology" Ministry of Health of Russia
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Locally advanced cervical cancer (LACC) remains a pressing problem in gynecological oncology, characterized by a high risk of relapse and progression even with standard chemoradiotherapy. Uterine artery chemoembolization (UAC) is considered a promising area of complex treatment, but its effectiveness is largely determined by the clinical and morphological characteristics of the tumor. Materials and methods. A retrospective and prospective study was conducted of 108 patients with stage IIA–IIIB LACC who underwent treatment in 2018–2022. The main group (n=60) received UAC followed by chemoradiotherapy (CRT), the control group (n=48) — CRT only. Efficacy was assessed according to RECIST 1.1 criteria, relapse-free survival (RFS) and overall survival (OS) — according to the Kaplan–Meier method. Univariate and multivariate regression analysis and ROC analysis were used to analyze prognostic factors. Results. The use of CEMA + CRT provided a significantly higher frequency of complete tumor regression (70.0% versus 38.0%; p = 0.001), a significant decrease in the SCC level and a decrease in the residual tumor volume. Three-year RFS was 73.4% in the main group and 34.7% in the control (p = 0.003). Independent unfavorable prognostic factors were stage IIIB, tumor volume > 80 cm³, low differentiation degree (G3), adenocarcinoma and SCC level > 5.5 ng / ml. The constructed prognostic model showed high accuracy (AUC 0.78-0.82; sensitivity 72-80%; specificity 73-75%). Conclusions. Clinical and morphological characteristics of the tumor are of key importance in predicting the effectiveness of CEMA in patients with MRCC. Their comprehensive consideration allows identifying high-risk groups, personalizing treatment tactics, and justifying the use of CEMA as part of combined therapy programs.
Keywords:Cervical cancer, uterine artery chemoembolization, clinical and morphological characteristics, relapse-free survival, SCC antigen, prognostic model
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Citation link:
Guliyeva G. Z., Mkrtchyan L. S., Kucherov V. V., Krikunova L. I., Ivanov S. A., Kaprin A. D. CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF LOCALLY ADVANCED CERVICAL CANCER AS PREDICTORS OF THE EFFECTIVENESS OF UTERINE ARTERY CHEMOEMBOLIZATION // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2026. -№02. -С. 246-253 DOI 10.37882/2223-2966.2026.02.17 |
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