DIAGNOSIS OF ACUTE MYELOID LEUKEMIA MICRO RNA DYSREGULATION

Belova Elena Vladimirovna, Orlina Margarita Anatolyevna, Kogan Anastasia Sergeevna, Muratova Tatiana Evgenievna

MicroRNAs play an important role among non coding RNAs in the regulation of cellular levels of numerous unrelated microRNAs, which leads to the emergence of new genes. Dysregulation of microRNA synthesis mechanisms—which act as regulators of protein synthesis—is one of the main causes of oncogenesis. Since microRNAs can function both as oncogenes and as tumour suppressors, studying their regulatory mechanisms and applying knowledge about microRNAs in the diagnosis and treatment of cancer diseases is highly relevant and has significant practical value for the advancement of medicine.

Keywords:small RNAs, RNA interference (RNAi), double-stranded RNA (dsRNA), RNA editing, oncogenesis