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Application of the method HPLC-MS/MS with the aim of providing therapeutic drug monitoring of immunosuppressants cyclosporine a and everolimus

Oseshnyuk Rodion   (graduate student, Federal state budgetary scientific institution "Institute of experimental medicine", Saint-Petersburg)

Kolobova Ekaterina   (graduate student, The Federal State Budgetary Institute «The Nikiforov Russian Center of Emergency and Radiation Medicine» The Ministry of Russian Federation for Civil Defense, Saint-Petersburg)

Ushal Inna   (Candidate of Medical Sciences, The Federal State Budgetary Institute «The Nikiforov Russian Center of Emergency and Radiation Medicine» The Ministry of Russian Federation for Civil Defense, Saint-Petersburg)

Rodionov Gennady   (Candidate of Medical Sciences, The Federal State Budgetary Institute «The Nikiforov Russian Center of Emergency and Radiation Medicine» The Ministry of Russian Federation for Civil Defense, Saint-Petersburg)

Shabanov Petr   (Candidate of Medical Science, Federal state budgetary scientific institution "Institute of experimental medicine", Saint-Petersburg Federal state budgetary scientific institution "Institute of experimental medicine", Saint-Petersburg )

With the aim of therapeutic drug monitoring methods have been developed for the quantitative determination of pharmaceutical preparations chemotherapeutic purpose – cyclosporine a and everolimus. The basis of the developed methods – high performance liquid chromatography with mass spectrometric detection. All methods successfully implemented in the analysis of samples obtained from patients.

Keywords:therapeutic drug monitoring (TLM), pharmacokinetics, HPLC / MS, cyclosporine А, everolimus.
 

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Citation link:
Oseshnyuk R. , Kolobova E. , Ushal I. , Rodionov G. , Shabanov P. Application of the method HPLC-MS/MS with the aim of providing therapeutic drug monitoring of immunosuppressants cyclosporine a and everolimus // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2017. -№02. -С. 76-82
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