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The effect of hypothermia on the activity of Na, K-ATPase of synaptic membranes of rat brain

Guseynov German Omarovich  (associate Professor, Dagestan state medical Academy of Ministry of health of the Russian Federation)

The effect of moderate (30°C) and deep (20°C) short-term hypothermia and reduced glutathione on the activity of Na, K-ATPase of the synaptic membranes from rat brain has been investigated. The content of SH-groups and the SS-bonds in synaptosomal membrane proteins under hypothermia has also been studied. Hypothermia reduces the activity of synaptosomal membrane Na, K-ATPase. Inhibition of the enzyme depends on the depth of hypothermia. In the in vitro condition the incubation of the suspension of synaptosomes with the reduced glutathione does not affect on the activity of Na, K-ATPase in control, but increases the activity of the enzyme under hypothermia. At hypothermia the oxidation of the thiol groups of synaptosomal membrane proteins occurs, which correlates with the degree of inhibition of Na, K-ATPase. Possible mechanisms of inhibition of the enzyme at hypothermia are discussed.

Keywords:hypothermia; rats; proteins of the brain.
 

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Citation link:
Guseynov G. O. The effect of hypothermia on the activity of Na, K-ATPase of synaptic membranes of rat brain // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2017. -№11. -С. 72-74
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