CHANGES IN BLOOD NGAL CONTENT, UNDER DIFFERENT DEGREES OF INSUFFLATED GAS PRESSURE, IN RETROPERITONEAL ENDOSURGERY

Lobanov Yu. S., Tereshkov P. P., Lobanov S. L., Shapovalov K. G., Lobanov L. S.

In modern clinical practice, laparoscopic and retroperitoneal methods are widely used to access the retroperitoneal space. The creation of the space necessary for surgical actions is achieved by creating a pneumo- and retro-pneumoperitoneum with varying degrees of hypertension. We studied the dynamics of the level of the NGAL kidney damage marker in 162 patients operated on for kidney cysts. The study was performed by flow cytometry using Human Kidney Funtion Panel 2 Mix and Match Subpanel (For Serum/Plasma Samples). It was found that with a gentle hypertension regime (up to 12 mmHg), there are no significant changes in the NGAL level in the perioperative period. With a combination of the most aggressive factors (pressure regime over 12 mmHg.ct and the duration of the operation from 30 to 60 minutes), the NGAL level increases by 31% on the 3rd day after the operation. Pneumoperitoneum, when combined with these factors, has a slightly greater effect on NGAL levels than retropneumoperitoneum.

Keywords:pneumoperitoneum, retro-pneumoperitoneum, NGAL, retroperitoneal space.